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1

Betulinic acid as new activator of NF-κB: molecular mechanisms and implications for cancer therapy

Kasperczyk, Hubert, La Ferla-Brühl, Katia, Westhoff, Mike Andrew, Behrend, Lars, Zwacka, Ralf Michael, Debatin, Klaus-Michael, Fulda, Simone

Journal:

Year:

2005

Language:

english

File:

PDF, 331 KB

english, 2005

2

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

Close, Viola, Close, William, Kugler, Sabrina Julia, Reichenzeller, Michaela, Yosifov, Deyan Yordanov, Bloehdorn, Johannes, Pan, Leiling, Tausch, Eugen, Westhoff, Mike-Andrew, Döhner, Hartmut, Stilgen

Journal:

Year:

2018

Language:

english

File:

PDF, 878 KB

english, 2018

3

Adhesion-mediated apoptosis resistance in cancer

Mike-Andrew Westhoff, Simone Fulda

Journal:

Drug Resistance Updates

Year:

2009

Language:

english

File:

PDF, 701 KB

english, 2009

4

Transitory dasatinib-resistant states in KITmut t(8;21) acute myeloid leukemia cells correlate with altered KIT expression

Herrmann, Markus D., Lennerz, Jochen K., Bullinger, Lars, Bartholomae, Stephan, Holzmann, Karlheinz, Westhoff, Mike-Andrew, Corbacioglu, Selim, Debatin, Klaus-Michael

Journal:

Experimental Hematology

Year:

2014

Language:

english

File:

PDF, 2.82 MB

english, 2014

5

PUBLIC PROPAGANDA AGAINST CANCER.

Westhoff, Mike-Andrew

Journal:

Year:

1922

Language:

english

File:

PDF, 420 KB

english, 1922

6

Strange inheritance

Westhoff, Mike-Andrew

Journal:

Year:

2008

Language:

english

File:

PDF, 75 KB

english, 2008

7

Phosphoinositide 3-Kinases Upregulate System x c−via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, Jan, Baxter, Paul, Kassubek, Rebecca, Albrecht, Philipp, Van Liefferinge, Joeri, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Karpel-Massler, Georg, Meakin, Paul J., Hayes, John D., Aronica,

Journal:

Antioxidants & Redox Signaling

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

8

Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide’s antiproliferative effect

Karpel-Massler, Georg, Kast, Richard Eric, Westhoff, Mike-Andrew, Dwucet, Annika, Welscher, Nathalie, Nonnenmacher, Lisa, Hlavac, Michal, Siegelin, Markus David, Wirtz, Christian Rainer, Debatin, Klau

Journal:

Journal of Neuro-Oncology

Year:

2015

Language:

english

File:

PDF, 3.19 MB

english, 2015

9

Cancer therapy: know your enemy?

Westhoff, Mike-Andrew, Brühl, Oliver, Debatin, Klaus-Michael

Journal:

Molecular and Cellular Pediatrics

Year:

2014

Language:

english

File:

PDF, 1.44 MB

english, 2014

10

A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy

Westhoff, Mike-Andrew, Karpel-Massler, Georg, Brühl, Oliver, Enzenmüller, Stefanie, La Ferla-Brühl, Katia, Siegelin, Markus D, Nonnenmacher, Lisa, Debatin, Klaus-Michael

Journal:

Molecular and Cellular Therapies

Year:

2014

Language:

english

File:

PDF, 1.55 MB

english, 2014

11

RIST: A potent new combination therapy for glioblastoma

Nonnenmacher, Lisa, Westhoff, Mike-Andrew, Fulda, Simone, Karpel-Massler, Georg, Halatsch, Marc-Eric, Engelke, Jens, Simmet, Thomas, Corbacioglu, Selim, Debatin, Klaus-Michael

Journal:

International Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

12

Killing Me Softly—Future Challenges in Apoptosis Research

Westhoff, Mike-Andrew, Brühl, Oliver, Nonnenmacher, Lisa, Karpel-Massler, Georg, Debatin, Klaus-Michael

Journal:

International Journal of Molecular Sciences

Year:

2014

Language:

english

File:

PDF, 2.27 MB

english, 2014

13

Cathepsin G-mediated proteolytic degradation of MHC class I molecules to facilitate immune detection of human glioblastoma cells

Palesch, David, Wagner, Johanna, Meid, Annika, Molenda, Nicole, Sienczyk, Marcin, Burkhardt, Jutta, Münch, Jan, Prokop, Lea, Stevanovic, Stefan, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Wirtz, Chri

Journal:

Cancer Immunology, Immunotherapy

Year:

2016

Language:

english

File:

PDF, 1.80 MB

english, 2016

14

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

Bischof, Joachim, Westhoff, Mike-Andrew, Wagner, Johanna Elisabeth, Halatsch, Marc-Eric, Trentmann, Stephanie, Knippschild, Uwe, Wirtz, Christian Rainer, Burster, Timo

Journal:

Year:

2017

Language:

english

File:

PDF, 792 KB

english, 2017

15

Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification

Karpel-Massler, Georg, Kast, Richard E., Siegelin, Markus D., Dwucet, Annika, Schneider, Elisabeth, Westhoff, Mike-Andrew, Wirtz, Christian Rainer, Chen, Xiao Yun, Halatsch, Marc-Eric, Bolm, Carsten

Journal:

Neurochemical Research

Year:

2017

Language:

english

File:

PDF, 1.40 MB

english, 2017

16

Cell death-based treatment of childhood cancer

Westhoff, Mike-Andrew, Marschall, Nicolas, Grunert, Michael, Karpel-Massler, Georg, Burdach, Stefan, Debatin, Klaus-Michael

Journal:

Cell Death and Disease

Year:

2018

Language:

english

File:

PDF, 1.68 MB

english, 2018

17

Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma

Zhang, Yiru, Ishida, Chiaki Tsuge, Shu, Chang, Kleiner, Giulio, Sanchez-Quintero, Maria J., Bianchetti, Elena, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 8.00 MB

english, 2018

18

Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and elicits Synthetic Lethality in Glioblastoma

Zhang, Yiru, Ishida, Chiaki Tsuge, Ishida, Wataru, Lo, Sheng-fu L, Zhao, Junfei, Shu, Chang, Bianchetti, Elena, Kleiner, Giulio, Sanchez-Quintero, Maria, Quinzii, Catarina M., Westhoff, Mike-Andrew, K

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 7.23 MB

english, 2018

19

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

Ströbele, Stephanie, Schneider, Matthias, Schneele, Lukas, Siegelin, Markus D., Nonnenmacher, Lisa, Zhou, Shaoxia, Karpel-Massle, Georg, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Debatin, Klaus-Mich

Journal:

Year:

2015

Language:

english

File:

PDF, 4.80 MB

english, 2015

20

Cerebral Microstructural Alterations after Radiation Therapy in High-Grade Glioma: A Diffusion Tensor Imaging-Based Study

Kassubek, Rebecca, Gorges, Martin, Westhoff, Mike-Andrew, Ludolph, Albert C., Kassubek, Jan, Müller, Hans-Peter

Journal:

Frontiers in Neurology

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

21

Metabolic Reprogramming by Dual AKT/ERK Inhibition Through Imipridones Elicits Unique Vulnerabilities in Glioblastoma

Ishida, Chiaki Tsuge, Zhang, Yiru, Bianchetti, Elena, Shu, Chang, Nguyen, Trang TT, Kleiner, Giulio, Sanchez-Quintero, Maria, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Prabhu

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 8.42 MB

english, 2018

22

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

Karpel-Massler, Georg, Banu, Matei A., Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.

Journal:

Year:

2016

Language:

english

File:

PDF, 6.58 MB

english, 2016

23

Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems

Shang, Enyuan, Zhang, Yiru, Shu, Chang, Ishida, Chiaki Tsuge, Bianchetti, Elena, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 5.35 MB

english, 2018

24

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids

Cwiklowska, Kamila, Westhoff, Mike‑Andrew, Freisinger, Simon, Dwucet, Annika, Halatsch, Marc‑Eric, Knippschild, Uwe, Debatin, Klaus‑Michael, Schirmbeck, Reinhold, Winiarski, Lukasz, Oleksyszyn, Jozef,

Journal:

Oncology Letters

Year:

2018

Language:

english

File:

PDF, 1000 KB

english, 2018

25

EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY

Hlavac, Michal, Dwucet, Annika, Westhoff, Mike-Andrew, Kast, Richard Eric, Engelke, Jens, Siegelin, Markus, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Karpel-Massler, Georg

Journal:

Year:

2018

Language:

english

File:

PDF, 119 KB

english, 2018

26

Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis

Hlavac, Michal, Dwucet, Annika, Kast, Richard Eric, Engelke, Jens, Westhoff, Mike-Andrew, Siegelin, Markus D., Debatin, Klaus-Michael, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Karpel-Massler, Geo

Journal:

Cellular Oncology

Year:

2019

File:

PDF, 2.83 MB

2019

27

Precision medicine in pediatric oncology

Burdach, Stefan E. G., Westhoff, Mike-Andrew, Steinhauser, Maximilian Felix, Debatin, Klaus-Michael

Journal:

Molecular and Cellular Pediatrics

Year:

2018

Language:

english

File:

PDF, 1.40 MB

english, 2018

28

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

Strobel, Hannah, Baisch, Tim, Fitzel, Rahel, Schilberg, Katharina, Siegelin, Markus D., Karpel-Massler, Georg, Debatin, Klaus-Michael, Westhoff, Mike-Andrew

Journal:

Year:

2019

Language:

english

File:

PDF, 993 KB

english, 2019

29

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

Strobel, Hannah, Baisch, Tim, Fitzel, Rahel, Schilberg, Katharina, Siegelin, Markus D., Karpel-Massler, Georg, Debatin, Klaus-Michael, Westhoff, Mike-Andrew

Journal:

Year:

2019

File:

PDF, 993 KB

2019

30

Comment in Response to âTemozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy etc. by B. Kainaâ

Westhoff, Mike-Andrew, Baisch, Tim, Herbener, Verena J., Karpel-Massler, Georg, Debatin, Klaus-Michael, Strobel, Hannah

Journal:

Year:

2020

File:

PDF, 204 KB

2020

31

Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems

Nguyen, Trang T. T., Zhang, Yiru, Shang, Enyuan, Shu, Chang, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.

Journal:

Year:

2020

File:

PDF, 3.75 MB

2020

32

Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma

Shang, Enyuan, Nguyen, Trang T. T., Shu, Chang, Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.

Journal:

Year:

2020

File:

PDF, 4.49 MB

2020

33

Aktuelle Behandlungskonzepte fÃ¼r Hirntumoren im Kindes- und Jugendalter

Peraud, Aurelia, Schuler-Ortoli, Marie, Stursberg, Jana, SchlÃ¶tzer, Wiebke, Beer, Meinrad, BartholomÃ¤, Stephan, Westhoff, Mike-Andrew, Welte, Birgitta, Wiegel, Thomas, Loichinger, Wolfgang, Debatin,

Journal:

Pädiatrie up2date

Year:

2020

File:

PDF, 1.06 MB

2020

34

CBMT-35. METABOLIC REWIRING BY ONC201/TIC10 AND 2-DEOXYGLUCOSE HAS SYNERGISTIC ANTI-GLIOBLASTOMA ACTIVITY

Pruss, Maximilian, Dwucet, Annika, Hlavac, Michal, Kast, Richard, Westhoff, Mike-Andrew, Wirtz, Rainer, Halatsch, Marc-Eric, Siegelin, Markus, Karpel-Massler, Georg

Journal:

Year:

2019

File:

PDF, 132 KB

2019